Peptide · Investigational

Sermorelin

A growth-hormone-releasing hormone (1-29) fragment once FDA-approved (Geref), now supplied mainly via compounding pharmacies.

Key facts

  • Also known as: Geref
  • Status: Investigational
  • Used for: GHRH (formerly approved)
  • Natural counterpart: The 1-29 fragment of natural GHRH.
  • Target enzyme / receptor: GHRH receptor (GHRHR) — class B GPCR
  • Signalling pathway: Gαs → cAMP → pituitary growth-hormone release
    In plain terms: Nudges the pituitary to release growth hormone.
  • Crystal / cryo-EM structure: Available  PDB 7CZ5 ↗

Status & safety

This peptide is investigational, or approved only in some regions — it is not a general consumer product. Treat online sellers with caution and speak to a clinician.

Research & clinical studies

Explore the biochemistry and clinical evidence for Sermorelin — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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