Peptide · Approved

Setmelanotide

A melanocortin-4-receptor agonist (Imcivree) for specific rare genetic forms of obesity.

Key facts

  • Also known as: Imcivree
  • Status: Approved
  • Used for: Rare genetic obesity
  • Natural counterpart: Mimics α-MSH acting on MC4R in the appetite pathway.
  • Target enzyme / receptor: Melanocortin-4 receptor (MC4R) — GPCR
  • Signalling pathway: Gαs → cAMP → restores appetite/energy-balance signalling → ↓appetite
    In plain terms: Restores the brain fullness signal to curb appetite in rare genetic obesity.
  • Crystal / cryo-EM structure: Available  PDB 7PIU ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Setmelanotide — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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