Peptide · Approved

Bivalirudin

A direct thrombin-inhibitor peptide (Angiomax) used as an anticoagulant during procedures.

Key facts

  • Also known as: Angiomax
  • Status: Approved
  • Used for: Anticoagulant
  • Natural counterpart: A synthetic analog of hirudin, the leech’s natural anticoagulant.
  • Target enzyme / receptor: Thrombin (Factor IIa) — a serine protease (enzyme, directly inhibited)
  • Signalling pathway: Blocks thrombin's active site & exosite → no fibrin formation → anticoagulation
    In plain terms: Directly jams thrombin, the clot-forming enzyme, so blood stays thin.
  • Crystal / cryo-EM structure: Available  PDB 1PPB ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Bivalirudin — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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