Peptide · Approved

Dulaglutide

A once-weekly GLP-1 receptor agonist (Trulicity) for type-2 diabetes. Prescription-only.

Key facts

  • Also known as: Trulicity
  • Status: Approved
  • Used for: Diabetes (GLP-1)
  • Natural counterpart: Mimics natural GLP-1 (an incretin hormone).
  • Target enzyme / receptor: GLP-1 receptor (GLP-1R) — class B GPCR
  • Signalling pathway: Gαs → cAMP → PKA → insulin secretion; slowed gastric emptying
    In plain terms: Boosts insulin when sugar is high, slows digestion, and reduces appetite.
  • Crystal / cryo-EM structure: Available  PDB 5VAI ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Dulaglutide — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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