Peptide · Supplement

Lactotripeptides

Milk-derived tripeptides (Ile-Pro-Pro and Val-Pro-Pro) that inhibit ACE and may modestly lower blood pressure.

Key facts

  • Also known as: IPP / VPP
  • Status: Supplement
  • Used for: Blood pressure (dairy, ACE)
  • Natural counterpart: Released from milk casein during digestion/fermentation (food-derived).
  • Target enzyme / receptor: Angiotensin-converting enzyme (ACE) — a zinc metallopeptidase (enzyme, inhibited)
  • Signalling pathway: Block ACE → less angiotensin I→II → renin–angiotensin system down → lower blood pressure
    In plain terms: Blocks the ACE enzyme, so less blood-pressure-raising angiotensin II forms.
  • Crystal / cryo-EM structure: Available  PDB 1O86 ↗
  • Sequence: IPP (Ile-Pro-Pro) · VPP (Val-Pro-Pro)

Status & safety

This peptide is sold legally as a dietary supplement. Supplements are not reviewed for effectiveness before sale, so quality varies by brand.

Research & clinical studies

Explore the biochemistry and clinical evidence for Lactotripeptides — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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