Peptide · Approved

Leuprolide

A GnRH agonist (Lupron) that shuts down sex-hormone production; used in prostate cancer, endometriosis and precocious puberty.

Key facts

  • Also known as: Lupron
  • Status: Approved
  • Used for: Cancer, endometriosis (GnRH agonist)
  • Natural counterpart: A superagonist analog of natural GnRH.
  • Target enzyme / receptor: GnRH receptor (GnRHR) — class A GPCR
  • Signalling pathway: Gαq → initial LH/FSH surge, then receptor down-regulation → ↓sex hormones
    In plain terms: Constant stimulation first spikes, then shuts down, sex-hormone production.
  • Crystal / cryo-EM structure: Available  PDB 7BR3 ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Leuprolide — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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