Peptide · Approved

Linaclotide

A gut peptide (Linzess) that activates guanylate cyclase-C for IBS with constipation.

Key facts

  • Also known as: Linzess
  • Status: Approved
  • Used for: IBS-C, constipation
  • Natural counterpart: Mimics guanylin & uroguanylin, the gut’s natural GC-C hormones.
  • Target enzyme / receptor: Guanylate cyclase-C (GC-C) — a receptor enzyme
  • Signalling pathway: ↑intracellular cGMP → CFTR channel → intestinal fluid secretion
    In plain terms: Raises cGMP in the gut lining, drawing in fluid to soften stool.
  • Crystal structure: no peptide–target complex in the PDB yet — study the target ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Linaclotide — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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