Peptide · Approved

Nafarelin

A GnRH-agonist nasal spray (Synarel) for endometriosis and precocious puberty.

Key facts

  • Also known as: Synarel
  • Status: Approved
  • Used for: Endometriosis (GnRH agonist)
  • Natural counterpart: An analog of natural GnRH.
  • Target enzyme / receptor: GnRH receptor (GnRHR) — GPCR
  • Signalling pathway: Gαq → down-regulation → ↓sex hormones
    In plain terms: Overstimulates then switches off sex-hormone output.
  • Crystal / cryo-EM structure: Available  PDB 7BR3 ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Nafarelin — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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