Peptide · Approved

Pramlintide

A synthetic amylin analog (Symlin) used with insulin to blunt post-meal blood-sugar spikes.

Key facts

  • Also known as: Symlin
  • Status: Approved
  • Used for: Diabetes (amylin analog)
  • Natural counterpart: Mimics amylin (IAPP), co-secreted with insulin by β-cells.
  • Target enzyme / receptor: Amylin receptor (calcitonin receptor + RAMP) — GPCR
  • Signalling pathway: Gαs → cAMP; slows gastric emptying and suppresses glucagon
    In plain terms: Works alongside insulin to slow digestion and curb after-meal appetite.
  • Crystal / cryo-EM structure: Available  PDB 8F0J ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Pramlintide — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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