Peptide · Approved

Ziconotide

A cone-snail-venom peptide (Prialt) delivered into the spinal fluid for severe chronic pain.

Key facts

  • Also known as: Prialt
  • Status: Approved
  • Used for: Severe chronic pain
  • Natural counterpart: A synthetic copy of ω-conotoxin MVIIA from cone-snail venom.
  • Target enzyme / receptor: N-type voltage-gated calcium channel (Caᵥ2.2)
  • Signalling pathway: Blocks Ca²⁺ influx at nerve terminals → ↓release of pain neurotransmitters
    In plain terms: Shuts calcium channels on pain nerves, silencing pain signals.
  • Crystal / cryo-EM structure: Available  PDB 7VFU ↗

Status & safety

This is an approved medicine — prescription-only in most countries. Only use it under a licensed clinician, obtained through a pharmacy.

Research & clinical studies

Explore the biochemistry and clinical evidence for Ziconotide — these open live, date-sorted searches, so they always show the latest.

Read research papers on PubMed ↗

Clinical studies (ClinicalTrials.gov) ↗ Google Scholar ↗ Related guide → All peptides & profiles →

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